Daclatasvir dihydrochloride
Description
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) dia mahery sy mavitrika am-bava.HCV NS5A proteininainhibitor amin'nyEC50s isan-karazany amin'ny 9-146 pM ho an'nykarazana genotypes HCV maro.Daclatasvir dihydrochloride koa dia aanion organika fitaterana polypeptide 1B (OATP1B)SYOATP1B3inhibitor amin'nyIC50s amin'ny 1.5 µM sy 3.27 µM, tsirairay avy.
IC50& Target
EC50: 50 pM (HCV replicon genotype 1a), 9 pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM (HCV replicon genotype 3a), 12 pM (HCV replicon genotype 4a) ary 33 pM HCV replicon genotype 5a)[1]
Kd: 8 nM (NS5A33-202) ary 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) ary 3.27 µM (OATP1B3)[3]
In Vitro
Daclatasvir (BMS-790052) dia mampiseho hetsika manakana mahery vaika amin'ny karazana génotype rehetra nosedraina, miaraka amin'ny EC50manomboka amin'ny 9 ora alina ka hatramin'ny 146 ora alina.Daclatasvir dia manakana ny HCV replicon genotype 1a, 1b, 2a, 3a, 4a ary 5a miaraka amin'ny EC50amin'ny 50 ora hariva, 9 ora alina, 71 alina, 146 alina, 12 ora alina ary 33 ora alina.Daclatasvir dia mpikatroka mahery vaika amin'ny otrik'aretina JFH-1 genotype 2a izay miverimberina ao amin'ny kolontsaina sela (EC).50=28 ora)[1].Daclatasvir (BMS-790052) dia mifamatotra mafy amin'ny NS5A33-202 sy NS5A26-202 miaraka amin'ny Kds amin'ny 8 nM sy 210 nM, tsirairay avy[2].
fitahirizana
| vovoka | -20°C | 3 taona |
| 4°C | 2 taona | |
| Amin'ny solvent | -80°C | 6 volana |
| -20°C | 1 volana |
Fitsapana klinika
| NCT laharana | Mpanohana | toe-javatra | Daty nanombohana | dingana |
| NCT03369327 | Tehran University of Medical Sciences|RojanPharma Pharmaceutical Company | Ny otrik'aretina hepatita C, valin'ny fitsaboana|virus tsy fahampian-tsakafon'ny olombelona | 1 Janoary 2017 | Dingana 3 |
| NCT03485846 | R-Pharm|Almedis | Hepatite C mitaiza Genotype 1b | 27 Novambra 2017 | Dingana 2 |
| NCT01016912 | Bristol-Myers Squibb | Ny aretina hepatita C | Desambra 2009 | Dingana 2 |
| NCT01629732 | Bristol-Myers Squibb | Virus hepatita C | Martsa 2013 | Dingana 2 |
| NCT01497834 | Bristol-Myers Squibb | Hepatita C | Janoary 2012 | Dingana 3 |
| Sary NCT01973049 | Bristol-Myers Squibb | Hepatita C | Desambra 2013 | Dingana 3 |
| NCT00663208 | Bristol-Myers Squibb | Hepatita C mitaiza | May 2008 | Dingana 2 |
| NCT02576314 | Foibem-pikarohana momba ny maha-olombelona sy ny fahasalamana|Hopitaly Beijing 302 | Ny aretina hepatita C mitaiza | Mey 2015 | Dingana 3 |
| NCT02756936 | Foibe fikarohana tena izy, Egypt|Zeta Pharmaceutical Industries | ara-pahasalamana | Febroary 2016 | Dingana 1 |
| Sary NCT02771405 | National Hepatology & Tropical Medicine Research Institute|University Cairo | Hepatita C, mitaiza|Carcinoma hepatocellular | Martsa 2016 | Dingana 3 |
| NCT03706898 | Viriom | VIH-1-infection|Faharavan'ny atiny | 1 Oktobra 2018 | Dingana 1 |
| Sary NCT02319031 | Bristol-Myers Squibb | Hepatita C | Febroary 2015 | Dingana 3 |
| Sary NCT02124044 | Ivon-toeram-pirenena momba ny fahasalamana ara-pahasalamana (CC)|Ivon-toerana nasionaly momba ny alèjy sy areti-mifindra (NIAID)|Bristol-Myers Squibb | VIH-HCV | Febroary 2014 | Dingana 2 |
| NCT02551861 | Bristol-Myers Squibb | Hepatita C | Desambra 2015 | Dingana 2 |
| NCT00859053 | Bristol-Myers Squibb | Ny tsy fahampian'ny atiny | Martsa 2009 | Dingana 1 |
| NCT01257204 | Bristol-Myers Squibb | Virus hepatita C | Desambra 2010 | Dingana 2 |
| NCT03063879 | Teheran University of Medical Sciences|Ahvaz Jundishapur University of Medical Sciences|Shiraz University of Medical Sciences|Hamadan University of Medical Sciences | Hepatite C, mitaiza|Tsy fahampian'ny voa | Aprily 1, 2017 | Dingana 4 |
| NCT01017575 | Bristol-Myers Squibb | Ny aretina hepatita C | Desambra 2009 | Dingana 2 |
| Sary NCT02865369 | Sang Gyune Kim|Hopitaly Boramae ao amin'ny Oniversiten'i Seoul|Hopitaly Severance|Hopitaly Oniversite Inha|Anjerimanontolon'i Korea|Université Gachon Gil Medical Center|Hopitaly Seoul University Hanyang|Hopitaly Ewha Womans University Mokdong|Hopitaly Bristol-Myers Squibb|Hopitaly University Soonchunhyang | Hepatita C mitaiza | Septambra 2016 |
|
| Sary NCT04070235 | Nanjing Sanhome Pharmaceutical, Co., Ltd. | Hepatita C, mitaiza | 29 martsa 2019 | Dingana 2 | Dingana 3 |
| NCT03487848 | Bristol-Myers Squibb | Hepatita C|Hepatita mitaiza | May 18, 2018 | Dingana 2 |
| NCT00904059 | Bristol-Myers Squibb | Hepatita C | Mey 2009 | Dingana 1 |
| Sary NCT02107365 | Ivontoerana Nasionaly Frantsay momba ny Fahasalamana sy Fikarohana ara-pitsaboana-Sampan-draharaham-pirenena frantsay misahana ny Fikarohana momba ny SIDA sy Hepatite Viral (Inserm-ANRS)|Bristol-Myers Squibb | Hepatita C otrik'aretina Genotype 4 | Novambra 2013 | Dingana 2 |
| NCT02397395 | Janssen R&D Ireland | Fahasimban'ny voa|Aretina voa amin'ny dingana farany | Mey 2015 | Dingana 2 |
| NCT03169348 | Oniversite Assiut | Hepatita C | 1 Novambra 2017 | Tsy mahakasika |
| NCT02323594 | Bristol-Myers Squibb | Ny aretina hepatita C | Desambra 2014 | Dingana 1 |
| NCT03537196 | Ivontoerana Nasionaly Frantsay momba ny Fahasalamana sy Fikarohana ara-pitsaboana-Sampan-draharaham-pirenena Frantsay misahana ny Fikarohana momba ny SIDA sy Hepatite Viral (Inserm-ANRS) | Hepatita C | Fampiasana zava-mahadomelina | Hepatitis C viraliny | 13 Novambra 2018 | Dingana 4 |
| Sary NCT02103569 | Bristol-Myers Squibb | Hepatita C | Aprily 2014 | Dingana 1 |
| NCT02772744 | Zagazig University|Cairo University | Hepatita C | 1 Novambra 2017 |
|
| NCT01718158 | Bristol-Myers Squibb | Hepatita C | Janoary 2013 | Dingana 3 |
| Sary NCT02496078 | Bristol-Myers Squibb | Hepatita C | Aogositra 2015 | Dingana 3 |
| NCT01425970 | Bristol-Myers Squibb | Hepatita C | Mey 2012 | Dingana 2 |
| NCT01471574 | Bristol-Myers Squibb | Hepatita C, Genotype 1 | Desambra 2011 | Dingana 3 |
| NCT01573351 | Bristol-Myers Squibb | Virus hepatita C | Mey 2012 | Dingana 3 |
| NCT01938625 | Janssen R&D Ireland | Hepatita C, mitaiza | 12 Desambra 2013 | Dingana 2 |
| NCT01492426 | Bristol-Myers Squibb | Hepatita C | Janoary 2012 | Dingana 3 |
| Sary NCT03480932 | Sekoly Johns Hopkins Bloomberg momba ny Fahasalamam-bahoaka|Ivon-toerana Nasionaly momba ny Fidorohana zava-mahadomelina (NIDA)|Ivotoerana YR Gaitonde momba ny fikarohana sy ny fanabeazana momba ny SIDA | Hepatita C, mitaiza | Febroary 2, 2018 | Dingana 2 | Dingana 3 |
| Sary NCT03163849 | Oniversite Assiut | Hepatite mitaiza c | Septambra 1, 2019 | Dingana 3 |
| NCT01581203 | Bristol-Myers Squibb | Virus hepatita C | Mey 2012 | Dingana 3 |
| NCT01492504 | Bristol-Myers Squibb | Hepatita C | Febroary 7, 2012 |
|
| NCT03686722 | Mohamed Raslan|University Ain Shams|Ivom-pikarohana zava-mahadomelina, Kairo, Ejipta | Diabeta Mellitus, karazana 2|Hepatita C|Fifandraisana amin'ny zava-mahadomelina | 9 septambra 2017 | Dingana 1 |
| NCT02262728 | Janssen Research & Development, LLC | Hepatita C, mitaiza | 30 septambra 2014 | Dingana 2 |
| Sary NCT02349048 | Janssen Research & Development, LLC | Virus hepatita C | Janoary 2015 | Dingana 2 |
| Sary NCT03882307 | Oniversite Assiut | Hepatita C, mitaiza | Mey 2020 | Dingana voalohany |
| Sary NCT02758509 | Parc de Salut Mar | Hepatita C | Cirrhose | 1 Janoary 2010 |
|
| NCT01795911 | Bristol-Myers Squibb | Hepatita C | Martsa 2013 | Dingana 2 |
| NCT03549832 | Assiut University|Sohag University|South Valley University | HCV Coinfection | 1 Janoary 2018 | Tsy mahakasika |
| NCT02161939 | Bristol-Myers Squibb | Hepatita C mitaiza |
| |
| NCT01309932 | Bristol-Myers Squibb | Hepatita C | Martsa 2011 | Dingana 2 |
| NCT01995266 | Bristol-Myers Squibb | Hepatita C | Febroary 28, 2014 | Dingana 3 |
| NCT02640157 | AbbVie | Hepatite C mitaiza|Virosin'ny hepatita C|Virosin'ny hepatita C Genotype 3 | Desambra 2015 | Dingana 3 |
| Sary NCT02032875 | Bristol-Myers Squibb | Hepatita C | Martsa 2014 | Dingana 3 |
| Sary NCT02624063 | Oniversite federaly São Paulo | Hepatita C, mitaiza | Desambra 2015 | Dingana 4 |
| NCT00546715 | Bristol-Myers Squibb | Hepatita C mitaiza | Novambra 2007 | Dingana 1 | Dingana 2 |
| NCT01718145 | Bristol-Myers Squibb | Ny otrikaretina hepatita C | Novambra 2012 | Dingana 3 |
| NCT01616524 | Bristol-Myers Squibb | Virus hepatita C (HCV) | Jolay 2012 | Dingana 3 |
| Sary NCT02032901 | Bristol-Myers Squibb | Hepatita C | Janoary 2014 | Dingana 3 |
| Sary NCT03540212 | Ain Shams University | Aretina HCV mitaiza | 10 Desambra 2017 | Dingana 2 | Dingana 3 |
| NCT02097966 | Bristol-Myers Squibb | Hepatita C mitaiza |
| |
| Sary NCT02596880 | Teheran University of Medical Sciences | Hepatita C|Cirrhose | Septambra 2015 | Dingana 3 |
| NCT04019717 | Ny sandan'ny anjara Atea Pharmaceuticals, Inc. | Hepatita C|Hepatita C, mitaiza|Hepatita C mitaiza|Hepatita C otrik'aretina|Hepatita C, aretina HCV | 20 jona 2019 | Dingana 2 |
| NCT02992457 | Tanta University | Hepatita C | Janoary 2015 | Dingana 4 |
| NCT03547895 | Oniversite Zagazig | Cirrhose decompensated | 1 Jona 2015 | Tsy mahakasika |
| NCT03004625 | Kaohsiung Medical University Chung-Ho Memorial Hospital|Chang Gung Memorial Hospital|National Taiwan University Hospital|Taipei Veterans General Hospital, Taiwan|China Medical University Hospital|National Cheng-Kung University Hospital | Hepatita C | Novambra 2016 | Dingana 3 |
| NCT01051414 | Bristol-Myers Squibb | Ny aretina hepatita C | Aprily 2010 | Dingana 2 |
| Sary NCT02309450 | Ivontoerana Nasionaly Frantsay momba ny Fahasalamana sy Fikarohana ara-pitsaboana-Sampan-draharaham-pirenena frantsay misahana ny Fikarohana momba ny SIDA sy Hepatite Viral (Inserm-ANRS)|Bristol-Myers Squibb | Hepatita C otrik'aretina Genotype 4 | Desambra 2014 | Dingana 2 |
| NCT01628692 | Bristol-Myers Squibb|Janssen Research & Development, LLC | Virus hepatita C | Jolay 2012 | Dingana 2 |
| NCT03186313 | Hopitaly Ati Ejiptiana|Hopitaly Wadi El Nil | Hepatita C | Septambra 2016 | Dingana 3 |
| NCT03063723 | Hopitaly Mifandray Fahatelo, Oniversite Sun Yat-Sen | Hepatita C mitaiza (fikorontanana) | 1 Janoary 2016 |
|
| NCT00983957 | Bristol-Myers Squibb | Hepatita C mitaiza | Oktobra 2009 | Dingana 1 |
| NCT01725542 | Ivontoerana Nasionaly Frantsay momba ny Fahasalamana sy Fikarohana ara-pitsaboana-Sampan-draharaham-pirenena frantsay misahana ny Fikarohana momba ny SIDA sy Hepatite Viral (Inserm-ANRS)|Bristol-Myers Squibb | HCV-HIV miaraka amin'ny aretina | Desambra 2012 | Dingana 2 |
| Sary NCT02282709 | Fondation ho an'ny fikarohana aty | Hepatita C mitaiza | Febroary 2014 | Dingana 3 |
| Sary NCT02032888 | Bristol-Myers Squibb | Hepatita C | Febroary 2014 | Dingana 3 |
| NCT03247296 | MTI University | Hepatita C | Febroary 28, 2017 |
|
| NCT01389323 | Bristol-Myers Squibb | Hepatita C | Septambra 2011 | Dingana 3 |
| Sary NCT02556086 | Bristol-Myers Squibb | Hepatita C | Desambra 2015 | Dingana 2 |
| NCT01741545 | Bristol-Myers Squibb | Virus hepatita C | 31 martsa 2013 | Dingana 3 |
| NCT01866930 | Bristol-Myers Squibb | Ny aretina hepatita C mitaiza | 11 Jolay 2013 | Dingana 3 |
| NCT02268864 | Janssen-Cilag International NV | Hepatita C, mitaiza | Janoary 2015 | Dingana 2 |
| NCT01797848 | Bristol-Myers Squibb | Hepatita C | Jona 2014 | Dingana 3 |
| Sary NCT03166280 | Eman Sayed Hassan Abd Allah|University Assiut | Hepatita C | Jona 2017 |
|
| NCT02159352 | Bristol-Myers Squibb | Hepatita C | Jona 2014 | Dingana 1 |
| NCT01125189 | Bristol-Myers Squibb | Virus hepatita C | Jolay 2010 | Dingana 2 |
| NCT03748745 | Nanjing Sanhome Pharmaceutical, Co., Ltd. | Fifandraisana amin'ny zava-mahadomelina | 19 Novambra 2018 | Dingana 1 |
| NCT01012895 | Bristol-Myers Squibb | Hepatita C mitaiza | Desambra 2009 | Dingana 2 |
| Sary NCT02565888 | Oniversite Radboud | Hepatite C|HIV | Novambra 2015 | Dingana 1 |
| NCT02555943 | Foibem-pikarohana momba ny maha-olombelona sy ny fahasalamana|Hopitaly Beijing 302|Hopitaly Nanfang ao amin'ny Oniversiten'ny Fitsaboana Tatsimo | Infection Chépatite C mitaiza|Confection HBV|Famerenana ny hepatita B | Febroary 2015 | Dingana 2 | Dingana 3 |
| Sary NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF|Ivom-pikarohana any Kalifornia Atsimo | Hepatita C|Cirrhose | Janoary 2015 | Dingana 4 |
| Sary NCT02580474 | Myeong Jun Song|Bristol-Myers Squibb|Hopitaly University Soonchunhyang|University Dankook|Hopitaly National University Chungnam|Hopitaly University Konyang|Hopitaly University Eulji|Hopitaly Saint Vincent, Korea|Hopitaly University Konkuk|Hopitaly St. Mary Cheongju, Cheongju , Korea|Hopitaly Severance|Hopitaly Guro University Korea|Hopitaly Lehibe Eulji|Ny Oniversite Katolika any Korea | Hepatita C | Febroary 2016 | Dingana 4 |
| Sary NCT02104843 | Bristol-Myers Squibb | Hepatita C | Aprily 2014 | Dingana 1 |
| Sary NCT01428063 | Bristol-Myers Squibb | Ny otrikaretina hepatita C | Septambra 2011 | Dingana 2 |
| NCT02123654 | Bristol-Myers Squibb | Ny otrikaretina hepatita C | Aprily 2014 | Dingana 3 |
| Sary NCT02565862 | Oniversite Radboud | Hepatita C|Diabeta Mellitus|Rehetra Insulin | Janoary 2016 | Dingana 1 |
| Sary NCT04211844 | Ain Shams University | Hepatita C mitaiza | 1 Oktobra 2019 |
|
| NCT00874770 | Bristol-Myers Squibb | Ny aretina hepatita C | Jona 2009 | Dingana 2 |
| NCT03883698 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | Ny tsy fahombiazan'ny voa, mitaiza|Hepatitis C | 15 martsa 2019 | Dingana 3 |
| NCT01448044 | Bristol-Myers Squibb | Hepatita C | Desambra 2011 | Dingana 3 |
| NCT01359644 | Bristol-Myers Squibb|Pharmasset | Hepatita C mitaiza | Jona 2011 | Dingana 2 |
| NCT01842451 | Ny sandan'ny anjara Vertex Pharmaceuticals Incorporated | Hepatita C|CHC|HCV|Hepatitis C | Jona 2013 | Dingana 2 |
| NCT02762448 | Hopitaly monisipaly ao Tainan | hepatita c | Jolay 2016 |
|
| Sary NCT02473211 | Foibem-pikarohana momba ny maha-olombelona sy ny fahasalamana|Hopitaly Beijing 302 | Ny aretina hepatita C mitaiza | Janoary 2015 | Dingana 2 | Dingana 3 |
| Sary NCT01455090 | Bristol-Myers Squibb | Hepatita C mitaiza | 30 Novambra 2011 | Dingana 2 |
| Sary NCT03490097 | Ain Shams University | Hepatita mitaiza c|Syndrome metabolika | 1 Desambra 2017 | Dingana 2 | Dingana 3 |
| NCT01170962 | Bristol-Myers Squibb | Virus hepatita C | Aogositra 2010 | Dingana 2 |
| NCT02333292 | Hopitaly University Valme|Hospital del SAS de Jerez|Hospital General Universitario Elche|Hospital La Línea de la Concepción|Complexo Hospitalario Universitario de A Coruña|Hospital de Figueres|Hospital Universitario Puerto Real|Hospital Universitario Virgen de la Victoria|Hospital Universitario de Canarias Hopitaly General Universitario de Alicante|Hospital Universitario Araba|Hospital Royo Vilanova|Hospital Universitario de Burgos|Complejo Hospitalario Universitario de Huelva|Hospital Universitario Reina Sofia de Cordoba|Hospital Universitario Virgen Macarena|Complexo Hospitalario Universitario de Navarra | Navarra|Hospital Clinico Universitario San Cecilio|Hospital Universitario La Fe|Hospital General Universitario de Valencia|Hospital Universitario Infanta Leonor|Hospital Universitario de Gran Canaria|Hospital General Universitario Santa Lucía|Centro Penitenciario Alicante 1|Hospital Virgen Regional Universitario | ny Luz|Hospital General Universitario de Castellón|Hospital Parc Taulí, Sabadell | Ny aretina hepatita C mitaiza | Desambra 2014 |
|
| Sary NCT03200184 | Teheran University of Medical Sciences | Hepatita C | 1 septambra 2016 | Dingana 4 |
| NCT03188276 | Hopitaly Mifandray Fahatelo, Oniversite Sun Yat-Sen | Hepatita C mitaiza | Febroary 1, 2016 | Dingana voalohany |
| Sary NCT01830205 | Bristol-Myers Squibb | Hepatita C | Septambra 2012 | Dingana 1 |
tolo-kevitra18Tetikasa fanombanana ny tsy fitoviana amin'ny kalitao izay nankatoavina4, ary6eo ambany fankatoavana ny tetikasa.
Ny rafitra fitantanana kalitao iraisam-pirenena mandroso dia nametraka fototra mafy ho an'ny varotra.
Ny fanaraha-maso kalitao dia mandeha amin'ny tsingerin'ny androm-piainan'ny vokatra mba hiantohana ny kalitao sy ny vokatra ara-pahasalamana.
Ny ekipan'ny Professional Regulatory Affairs dia manohana ny fitakiana kalitao mandritra ny fangatahana sy ny fisoratana anarana.
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