Daclatasvir dihydrochloride
Description
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) dia mahery sy mavitrika am-bava.HCV NS5A proteininainhibitor amin'nyEC50s isan-karazany ny 9-146 pM ho an'nykarazana genotypes HCV maro. Daclatasvir dihydrochloride dia aanion organika fitaterana polypeptide 1B (OATP1B)SYOATP1B3inhibitor amin'nyIC50s amin'ny 1.5 µM sy 3.27 µM, tsirairay avy.
IC50& Target
EC50: 50 pM (genotype HCV replicon 1a), 9 pM (genotype HCV replicon 1b), 71 pM (genotype HCV replicon 2a), 146 pM (genotype HCV replicon 3a), 12 pM (genotype HCV 33 pM) ary HCV replicon genotype 5a)[1]
Kd: 8 nM (NS5A33-202) sy 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) ary 3.27 µM (OATP1B3)[3]
In Vitro
Daclatasvir (BMS-790052) dia mampiseho hetsika manakantsakana mahery vaika amin'ny génotype rehetra nosedraina, miaraka amin'ny EC50manomboka amin'ny 9 ora alina ka hatramin'ny 146 ora alina. Daclatasvir dia manakana ny HCV replicon genotype 1a, 1b, 2a, 3a, 4a ary 5a miaraka amin'ny EC50amin'ny 50 ora hariva, 9 ora alina, 71 alina, 146 alina, 12 ora alina ary 33 ora alina. Daclatasvir dia mpikatroka mahery vaika amin'ny virosy JFH-1 genotype 2a izay miverimberina ao amin'ny kolontsaina sela (EC).50=28 ora)[1]. Daclatasvir (BMS-790052) dia mifamatotra mafy amin'ny NS5A33-202 sy NS5A26-202 miaraka amin'ny Kds ny 8 nM sy 210 nM, tsirairay avy[2].
fitahirizana
| vovoka | -20°C | 3 taona |
| 4°C | 2 taona | |
| Amin'ny solvent | -80°C | 6 volana |
| -20°C | 1 volana |
Fitsapana klinika
| NCT laharana | Sponsor | toe-javatra | Daty nanombohana | dingana |
| NCT03369327 | Teheran University of Medical Sciences|RojanPharma Pharmaceutical Company | Otrik'aretina hepatita C, valin'ny fitsaboana|virus tsy fahampian-tsakafon'ny olombelona | 1 Janoary 2017 | Dingana 3 |
| Sary NCT03485846 | R-Pharm|Almedis | Hepatite C mitaiza Genotype 1b | 27 Novambra 2017 | Dingana 2 |
| NCT01016912 | Bristol-Myers Squibb | Ny aretina hepatita C | Desambra 2009 | Dingana 2 |
| NCT01629732 | Bristol-Myers Squibb | Virus hepatita C | Martsa 2013 | Dingana 2 |
| NCT01497834 | Bristol-Myers Squibb | Hepatita C | Janoary 2012 | Dingana 3 |
| Sary NCT01973049 | Bristol-Myers Squibb | Hepatita C | Desambra 2013 | Dingana 3 |
| NCT00663208 | Bristol-Myers Squibb | Hepatita C mitaiza | May 2008 | Dingana 2 |
| Sary NCT02576314 | Foibem-pikarohana momba ny maha-olombelona sy ny fahasalamana|Hopitaly Beijing 302 | Ny aretina hepatita C mitaiza | Mey 2015 | Dingana 3 |
| NCT02756936 | Foibe fikarohana tena izy, Egypt|Zeta Pharmaceutical Industries | ara-pahasalamana | Febroary 2016 | Dingana 1 |
| Sary NCT02771405 | National Hepatology & Tropical Medicine Research Institute|University Cairo | Hepatita C, mitaiza|Carcinoma hepatocellular | Martsa 2016 | Dingana 3 |
| NCT03706898 | Viriom | VIH-1-infection|Faharavan'ny atiny | 1 Oktobra 2018 | Dingana 1 |
| Sary NCT02319031 | Bristol-Myers Squibb | Hepatita C | Febroary 2015 | Dingana 3 |
| Sary NCT02124044 | Ivon-toeram-pirenena momba ny fahasalamana ara-pahasalamana (CC)|Ivon-toerana nasionaly momba ny alèjy sy areti-mifindra (NIAID)|Bristol-Myers Squibb | VIH-HCV | Febroary 2014 | Dingana 2 |
| Sary NCT02551861 | Bristol-Myers Squibb | Hepatita C | Desambra 2015 | Dingana 2 |
| NCT00859053 | Bristol-Myers Squibb | Ny tsy fahampian'ny hepatika | Martsa 2009 | Dingana 1 |
| NCT01257204 | Bristol-Myers Squibb | Virus hepatita C | Desambra 2010 | Dingana 2 |
| Sary NCT03063879 | Teheran University of Medical Sciences|Ahvaz Jundishapur University of Medical Sciences|Shiraz University of Medical Sciences|Hamadan University of Medical Sciences | Hepatite C, mitaiza|Tsy fahampian'ny voa | Aprily 1, 2017 | Dingana 4 |
| NCT01017575 | Bristol-Myers Squibb | Ny aretina hepatita C | Desambra 2009 | Dingana 2 |
| Sary NCT02865369 | Sang Gyune Kim|Hopitaly Boramae ao amin'ny Oniversiten'i Seoul|Hopitaly Severance|Hopitaly Oniversite Inha|Université Korea|Université Gachon Gil Medical Center|Hopitaly Seoul University Hanyang|Hopitaly Ewha Womans University Mokdong|Hopitaly Bristol-Myers Squibb|Hopitaly University Soonchunhyang | Hepatita C mitaiza | Septambra 2016 |
|
| Sary NCT04070235 | Nanjing Sanhome Pharmaceutical, Co., Ltd. | Hepatita C, mitaiza | 29 martsa 2019 | Dingana 2 | Dingana 3 |
| NCT03487848 | Bristol-Myers Squibb | Hepatita C|Hepatita mitaiza | May 18, 2018 | Dingana 2 |
| NCT00904059 | Bristol-Myers Squibb | Hepatita C | Mey 2009 | Dingana 1 |
| Sary NCT02107365 | Ivon-toerana Nasionaly Frantsay momba ny Fahasalamana sy Fikarohana ara-pitsaboana-Sampan-draharaham-pirenena frantsay misahana ny Fikarohana momba ny SIDA sy Hepatite Viral (Inserm-ANRS)|Bristol-Myers Squibb | Ny otrikaretina hepatita C Genotype 4 | Novambra 2013 | Dingana 2 |
| NCT02397395 | Janssen R&D Ireland | Fahasimban'ny voa|Aretina voa amin'ny dingana farany | Mey 2015 | Dingana 2 |
| NCT03169348 | Oniversite Assiut | Hepatita C | 1 Novambra 2017 | Tsy mahakasika |
| NCT02323594 | Bristol-Myers Squibb | Ny aretina hepatita C | Desambra 2014 | Dingana 1 |
| NCT03537196 | Ivontoerana Nasionaly Frantsay momba ny Fahasalamana sy Fikarohana ara-pitsaboana-Sampan-draharaham-pirenena frantsay misahana ny Fikarohana momba ny SIDA sy Hepatite Viral (Inserm-ANRS) | Hepatita C | Fampiasana zava-mahadomelina | Hepatitis C viraliny | 13 Novambra 2018 | Dingana 4 |
| Sary NCT02103569 | Bristol-Myers Squibb | Hepatita C | Aprily 2014 | Dingana 1 |
| NCT02772744 | Zagazig University|Cairo University | Hepatita C | 1 Novambra 2017 |
|
| NCT01718158 | Bristol-Myers Squibb | Hepatita C | Janoary 2013 | Dingana 3 |
| Sary NCT02496078 | Bristol-Myers Squibb | Hepatita C | Aogositra 2015 | Dingana 3 |
| NCT01425970 | Bristol-Myers Squibb | Hepatita C | Mey 2012 | Dingana 2 |
| NCT01471574 | Bristol-Myers Squibb | Hepatita C, Genotype 1 | Desambra 2011 | Dingana 3 |
| NCT01573351 | Bristol-Myers Squibb | Virus hepatita C | Mey 2012 | Dingana 3 |
| NCT01938625 | Janssen R&D Ireland | Hepatita C, mitaiza | 12 Desambra 2013 | Dingana 2 |
| NCT01492426 | Bristol-Myers Squibb | Hepatita C | Janoary 2012 | Dingana 3 |
| Sary NCT03480932 | Sekoly Johns Hopkins Bloomberg momba ny Fahasalamam-bahoaka|Ivon-toerana Nasionaly momba ny Fanararaotana Zava-mahadomelina (NIDA)|Ivotoerana YR Gaitonde momba ny Fikarohana sy Fanabeazana SIDA | Hepatita C, mitaiza | Febroary 2, 2018 | Dingana 2 | Dingana 3 |
| Sary NCT03163849 | Oniversite Assiut | Hepatite mitaiza c | Septambra 1, 2019 | Dingana 3 |
| Sary NCT01581203 | Bristol-Myers Squibb | Virus hepatita C | Mey 2012 | Dingana 3 |
| NCT01492504 | Bristol-Myers Squibb | Hepatita C | Febroary 7, 2012 |
|
| NCT03686722 | Mohamed Raslan|Université Ain Shams|Ivom-pikarohana zava-mahadomelina, Kairo, Ejipta | Diabeta Mellitus, karazana 2|Hepatitis C|Fifandraisana amin'ny zava-mahadomelina | 9 septambra 2017 | Dingana 1 |
| NCT02262728 | Janssen Research & Development, LLC | Hepatita C, mitaiza | 30 septambra 2014 | Dingana 2 |
| Sary NCT02349048 | Janssen Research & Development, LLC | Virus hepatita C | Janoary 2015 | Dingana 2 |
| Sary NCT03882307 | Oniversite Assiut | Hepatita C, mitaiza | Mey 2020 | Dingana voalohany 1 |
| Sary NCT02758509 | Parc de Salut Mar | Hepatita C | Cirrhose | 1 Janoary 2010 |
|
| NCT01795911 | Bristol-Myers Squibb | Hepatita C | Martsa 2013 | Dingana 2 |
| NCT03549832 | Assiut University|Sohag University|South Valley University | HCV Coinfection | 1 Janoary 2018 | Tsy mahakasika |
| NCT02161939 | Bristol-Myers Squibb | Hepatita C mitaiza |
| |
| NCT01309932 | Bristol-Myers Squibb | Hepatita C | Martsa 2011 | Dingana 2 |
| NCT01995266 | Bristol-Myers Squibb | Hepatita C | Febroary 28, 2014 | Dingana 3 |
| NCT02640157 | AbbVie | Hepatita C mitaiza|Virosin'ny hepatita C|Virosin'ny hepatita C Genotype 3 | Desambra 2015 | Dingana 3 |
| Sary NCT02032875 | Bristol-Myers Squibb | Hepatita C | Martsa 2014 | Dingana 3 |
| Sary NCT02624063 | Oniversite Federalin'i São Paulo | Hepatita C, mitaiza | Desambra 2015 | Dingana 4 |
| NCT00546715 | Bristol-Myers Squibb | Hepatita C mitaiza | Novambra 2007 | Dingana 1 | Dingana 2 |
| NCT01718145 | Bristol-Myers Squibb | Ny otrikaretina hepatita C | Novambra 2012 | Dingana 3 |
| NCT01616524 | Bristol-Myers Squibb | Virus hepatita C (HCV) | Jolay 2012 | Dingana 3 |
| Sary NCT02032901 | Bristol-Myers Squibb | Hepatita C | Janoary 2014 | Dingana 3 |
| Sary NCT03540212 | Oniversite Ain Shams | Aretina HCV mitaiza | 10 Desambra 2017 | Dingana 2 | Dingana 3 |
| NCT02097966 | Bristol-Myers Squibb | Hepatita C mitaiza |
| |
| Sary NCT02596880 | Teheran University of Medical Sciences | Hepatita C|Cirrhose | Septambra 2015 | Dingana 3 |
| Sary NCT04019717 | Ny sandan'ny anjara Atea Pharmaceuticals, Inc. | Hepatita C|Hepatita C, mitaiza|Hepatita C mitaiza|Hepatita C otrik'aretina|Hepatita C, aretina HCV | 20 jona 2019 | Dingana 2 |
| NCT02992457 | Tanta University | Hepatita C | Janoary 2015 | Dingana 4 |
| NCT03547895 | Oniversite Zagazig | Cirrhose decompensated | 1 Jona 2015 | Tsy mahakasika |
| Sary NCT03004625 | Kaohsiung Medical University Chung-Ho Memorial Hospital|Chang Gung Memorial Hospital|National Taiwan University Hospital|Taipei Veterans General Hospital, Taiwan|China Medical University Hospital|National Cheng-Kung University Hospital | Hepatita C | Novambra 2016 | Dingana 3 |
| NCT01051414 | Bristol-Myers Squibb | Ny aretina hepatita C | Aprily 2010 | Dingana 2 |
| Sary NCT02309450 | Ivon-toerana Nasionaly Frantsay momba ny Fahasalamana sy Fikarohana ara-pitsaboana-Sampan-draharaham-pirenena frantsay misahana ny Fikarohana momba ny SIDA sy Hepatite Viral (Inserm-ANRS)|Bristol-Myers Squibb | Ny otrikaretina hepatita C Genotype 4 | Desambra 2014 | Dingana 2 |
| NCT01628692 | Bristol-Myers Squibb|Janssen Research & Development, LLC | Virus hepatita C | Jolay 2012 | Dingana 2 |
| NCT03186313 | Hopitaly Ati Ejiptiana|Hopitaly Wadi El Nil | Hepatita C | Septambra 2016 | Dingana 3 |
| NCT03063723 | Hopitaly Mifandray Fahatelo, Oniversite Sun Yat-Sen | Hepatita C mitaiza (fikorontanana) | 1 Janoary 2016 |
|
| NCT00983957 | Bristol-Myers Squibb | Hepatita C mitaiza | Oktobra 2009 | Dingana 1 |
| NCT01725542 | Ivon-toerana Nasionaly Frantsay momba ny Fahasalamana sy Fikarohana ara-pitsaboana-Sampan-draharaham-pirenena frantsay misahana ny Fikarohana momba ny SIDA sy Hepatite Viral (Inserm-ANRS)|Bristol-Myers Squibb | HCV-HIV miaraka amin'ny aretina | Desambra 2012 | Dingana 2 |
| Sary NCT02282709 | Fondation ho an'ny fikarohana aty | Hepatita C mitaiza | Febroary 2014 | Dingana 3 |
| Sary NCT02032888 | Bristol-Myers Squibb | Hepatita C | Febroary 2014 | Dingana 3 |
| NCT03247296 | MTI University | Hepatita C | Febroary 28, 2017 |
|
| NCT01389323 | Bristol-Myers Squibb | Hepatita C | Septambra 2011 | Dingana 3 |
| Sary NCT02556086 | Bristol-Myers Squibb | Hepatita C | Desambra 2015 | Dingana 2 |
| NCT01741545 | Bristol-Myers Squibb | Virus hepatita C | 31 martsa 2013 | Dingana 3 |
| NCT01866930 | Bristol-Myers Squibb | Ny aretina hepatita C mitaiza | 11 Jolay 2013 | Dingana 3 |
| NCT02268864 | Janssen-Cilag International NV | Hepatita C, mitaiza | Janoary 2015 | Dingana 2 |
| NCT01797848 | Bristol-Myers Squibb | Hepatita C | Jona 2014 | Dingana 3 |
| Sary NCT03166280 | Eman Sayed Hassan Abd Allah|University Assiut | Hepatita C | Jona 2017 |
|
| NCT02159352 | Bristol-Myers Squibb | Hepatita C | Jona 2014 | Dingana 1 |
| NCT01125189 | Bristol-Myers Squibb | Virus hepatita C | Jolay 2010 | Dingana 2 |
| Sary NCT03748745 | Nanjing Sanhome Pharmaceutical, Co., Ltd. | Fifandraisana amin'ny zava-mahadomelina | 19 Novambra 2018 | Dingana 1 |
| NCT01012895 | Bristol-Myers Squibb | Hepatita C mitaiza | Desambra 2009 | Dingana 2 |
| Sary NCT02565888 | Oniversite Radboud | Hepatite C|HIV | Novambra 2015 | Dingana 1 |
| NCT02555943 | Foibem-pikarohana momba ny maha-olombelona sy ny fahasalamana|Hopitaly Beijing 302|Hopitaly Nanfang ao amin'ny Oniversiten'i Southern Medical | Infection Chépatite C mitaiza|Confection HBV|Famerenana ny Hepatite B | Febroary 2015 | Dingana 2 | Dingana 3 |
| Sary NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF|Ivom-pikarohana any Kalifornia Atsimo | Hepatita C|Cirrhose | Janoary 2015 | Dingana 4 |
| Sary NCT02580474 | Myeong Jun Song|Bristol-Myers Squibb|Hopitaly University Soonchunhyang|University Dankook|Hopitaly National University Chungnam|Hopitaly Anjerimanontolo Konyang|Hopitaly Anjerimanontolon'i Eulji|Hopitaly Saint Vincent, Korea|Hopitaly Oniversite Konkuk|Hopitaly Cheongju St. Mary, Cheongju , Korea|Hopitaly Severance|Hopitaly Guro University Korea|Hopitaly General Eulji|Ny Oniversite Katolika any Korea | Hepatita C | Febroary 2016 | Dingana 4 |
| Sary NCT02104843 | Bristol-Myers Squibb | Hepatita C | Aprily 2014 | Dingana 1 |
| Sary NCT01428063 | Bristol-Myers Squibb | Ny otrikaretina hepatita C | Septambra 2011 | Dingana 2 |
| NCT02123654 | Bristol-Myers Squibb | Ny otrikaretina hepatita C | Aprily 2014 | Dingana 3 |
| Sary NCT02565862 | Oniversite Radboud | Hepatita C|Diabeta Mellitus|Rehetra Insulin | Janoary 2016 | Dingana 1 |
| Sary NCT04211844 | Oniversite Ain Shams | Hepatita C mitaiza | 1 Oktobra 2019 |
|
| NCT00874770 | Bristol-Myers Squibb | Ny aretina hepatita C | Jona 2009 | Dingana 2 |
| NCT03883698 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | Ny tsy fahombiazan'ny voa, mitaiza|Hepatitis C | 15 martsa 2019 | Dingana 3 |
| NCT01448044 | Bristol-Myers Squibb | Hepatita C | Desambra 2011 | Dingana 3 |
| NCT01359644 | Bristol-Myers Squibb|Pharmasset | Hepatita C mitaiza | Jona 2011 | Dingana 2 |
| NCT01842451 | Ny sandan'ny anjara Vertex Pharmaceuticals Incorporated | Hepatita C|CHC|HCV|Hepatitis C | Jona 2013 | Dingana 2 |
| NCT02762448 | Hopitaly monisipaly Tainan | hepatita c | Jolay 2016 |
|
| Sary NCT02473211 | Foibem-pikarohana momba ny maha-olombelona sy ny fahasalamana|Hopitaly Beijing 302 | Ny aretina hepatita C mitaiza | Janoary 2015 | Dingana 2 | Dingana 3 |
| Sary NCT01455090 | Bristol-Myers Squibb | Hepatita C mitaiza | 30 Novambra 2011 | Dingana 2 |
| Sary NCT03490097 | Oniversite Ain Shams | Hepatita mitaiza c|Syndrome metabolika | 1 Desambra 2017 | Dingana 2 | Dingana 3 |
| NCT01170962 | Bristol-Myers Squibb | Virus hepatita C | Aogositra 2010 | Dingana 2 |
| NCT02333292 | Hopitaly University Valme|Hospital del SAS de Jerez|Hospital General Universitario Elche|Hospital La Línea de la Concepción|Complexo Hospitalario Universitario de A Coruña|Hospital de Figueres|Hospital Universitario Puerto Real|Hospital Universitario Virgen de la Victoria|Hospital Universitario de Canarias Hopitaly Général Universitario de Alicante|Hôpitaly Universitario Araba|Hospital Royo Vilanova|Hospital Universitario de Burgos|Complejo Hospitalario Universitario de Huelva|Hospital Universitario Reina Sofia de Cordoba|Hospital Universitario Virgen Macarena|Complexo Hospitalario Universitario de Vigo|Clinica Universidad|Universidad de Navarra, Universidad de Navarra Cecilio|Hospital Universitario La Fe|Hospital General Universitario de Valencia|Hospital Universitario Infanta Leonor|Hospital Universitario de Gran Canaria|Hospital General Universitario Santa Lucía|Centro Penitenciario Alicante 1|Hospital Regional Universitario Carlos Haya|Hospital Virgen de la Generalz de Castellón|Hospital Parc Taulí, Sabadell | Ny aretina hepatita C mitaiza | Desambra 2014 |
|
| Sary NCT03200184 | Teheran University of Medical Sciences | Hepatita C | 1 septambra 2016 | Dingana 4 |
| Sary NCT03188276 | Hopitaly Mifandray Fahatelo, Oniversite Sun Yat-Sen | Hepatita C mitaiza | Febroary 1, 2016 | Dingana voalohany 1 |
| Sary NCT01830205 | Bristol-Myers Squibb | Hepatita C | Septambra 2012 | Dingana 1 |
tolo-kevitra18Tetikasa fanombanana ny tsy fitoviana amin'ny kalitao izay nankatoavina4, ary6eo ambany fankatoavana ny tetikasa.
Ny rafitra fitantanana kalitao iraisam-pirenena mandroso dia nametraka fototra mafy ho an'ny varotra.
Ny fanaraha-maso ny kalitao dia mandeha amin'ny tsingerin'ny fiainan'ny vokatra mba hiantohana ny kalitao sy ny vokatra ara-pahasalamana.
Ny ekipan'ny Professional Regulatory Affairs dia manohana ny fitakiana kalitao mandritra ny fampiharana sy ny fisoratana anarana.
Korea Countec Bottled Packaging Line
Taiwan CVC tavoahangy fonosana tsipika
Italiana CAM Board Packaging Line
German Fette Compacting Machine
Japon Viswill Tablet Detector
Efitrano fanaraha-maso DCS
Fiaraha-miasa iraisam-pirenena
Fiaraha-miasa ao an-tokantrano
Soraty eto ny hafatrao ary alefaso aminay
